Excuse the poor quality of this clip, but I just had to show it to you anyway.
Eminem makes a surprise cameo in Judd Apatow's Funny People (2009). He plays one of the main character's celebrity friends, attending a "you're not sick anymore" party. But leave it to Mr. Mathers to be full of doom and gloom, with the worst possible outlook on the otherwise happy situation.
Let this clip also serve as a reminder that Em can actually act.